2 Ginseng on myocardial energy metabolism in ischemic rats.docVIP

 PAGE \* MERGEFORMAT 4 2 Ginseng on myocardial energy metabolism in ischemic rats [Abstract] Objective: Intraperitoneal injection of pituitrin caused by myocardial ischemia model in rats to observe the two Ginseng on myocardial ischemia protection. Methods: 60 Wistar rats were divided into normal control group, model group, 2 Ginseng low, medium and high dose group, enteric-coated aspirin group to observe two rats in each group Ginseng on ECG, serum LDH, CK and myocardial effects of ATP. Results: 2 Ginseng can confront intraperitoneal injection of pituitrin caused by myocardial ischemia and injury, so that myocardial ischemia in rats increased the number of abnormal ST-segment reduction, can significantly reduce the serum CK and LDH release, protection of myocardial ATP activity. Conclusion: The two Ginseng on myocardial ischemia has a protective effect and its mechanism may be related to anti-free radical and anti-lipid peroxidation reaction. [Keywords:] 2 Ginseng; myocardial ischemia; energy metabolism; rat Ginseng has a two Yiqihuoxue, Tongluo analgesic effect. After extensive clinical observation showed that their ischemic heart disease, angina has a good effect. In order to further clarify its mechanism of action, to validate its efficacy, we observed the drug on pituitrin-induced myocardial ischemia injury for the clinical application of two Ginseng treatment of cardiovascular disease, provides a theoretical basis. 1 Materials and methods 1.1 Experimental animals and 70 drug Wistar rats, weighing 250-300 g ,8-10-week-old, male, purchased from the Experimental Animal Center of Changchun Development Zone. 2 Ginseng (Astragalus, Codonopsis, Salvia, Chuanxiong, descending incense, Ophiopogon, Schisandra, costas, scallion white, 37, leeches, licorice), vasopressin, ATP enzyme test kit, LDH test kit, CK Test Kit were purchased from Nanjing Jiancheng Bio-Engineering Institute. 1.2 Experimental Methods The rats were randomly divided into six groups of 10 ra