5 - fluorouracil continuous infusion for patients with oral ulcers caused bydegree of care.docVIP

 PAGE \* MERGEFORMAT 7 5 - fluorouracil continuous infusion for patients with oral ulcers caused bydegree of care [Keywords:] oral mucositis; 5 - fluorouracil; Care 5 - fluorouracil (5-FU) to uracil antimetabolite class, is a cell cycle specific drug, the oral mucosa of active proliferation inhibition and cell killing effect, causing oral lesions. It is reported that ,5-FU continuous intravenous infusion treatment of digestive tract tumors, a higher incidence of side effects are severe oral ulcers. oral ulcers caused pain not only to patients, but also affect the normal eating, can cause serious systemic infection, leading to disruption and even failure of the common chemotherapy reasons [1] .2008 September to August 2009 our department with low-dose continuous infusion 5-FU chemotherapy in 52 patients, 28 patients had oral ulcers grade . According to the appropriate clinical treatment and care measures No case of infection were cured, the final report is as follows. 1 Data and methods 1.1 General Information from September 2008 to August 2009 Wuwei County People’s Hospital, Oncology, continuous infusion with 5-FU chemotherapy in 52 patients, aged 32 to 67 years, mean 45 years old; 28 patients with oral ulcers appeared grade .52 cases, 20 cases of colon cancer, rectal cancer, 12 cases of gastric cancer in 16 cases, 3 cases of esophageal cancer, renal cell carcinoma in 1 case. chemotherapy regimen commonly used standard for domestic programs (FP). using quantitative low-dose 5-FU continuous intravenous drip, times are 120 h. in the first 5 days of chemotherapy with oral ulcers, the main clinical manifestations: erythema early as the cheek, followed by the lips, tongue, floor of mouth, the buccal erosion, ulcer formation, the depth to the submucosa; patients complained of pain , can not eat, pronunciation. after the treatment and care, no case of infection in this group, the average 15-day recovery. 1.2 Treatment 1.2.1 improve immunity because