About EMMPRIN in papillary thyroid carcinoma tissues and its significance.docVIP

 PAGE \* MERGEFORMAT 13 About EMMPRIN in papillary thyroid carcinoma tissues and its significance [Abstract] Objective: To investigate the extracellular matrix metalloproteinase inducer (extracellular matrix matalloproteinase inducer, EMMPRIN) in papillary thyroid carcinoma tissues and its clinical significance. Methods: The People’s Hospital of Wuhan University from 2004 to 2009, surgical resection and biopsy specimens of 40 papillary thyroid cancer patients, an alternative cancer, 5 cases of the surrounding tissue as control. immunohistochemical tissue of each group observed the expression of EMMPRIN. using HPIAS 2000 image analysis system in the above groups EMMPRIN expression The average optical density and the average rate of positive area. Results: Thyroid cancer tissues showed high expression of EMMPRIN; cancer tissues showed low expression of EMMPRIN. image analysis results showed that: papillary thyroid carcinoma and adjacent tissues, the average between the optical density and EMMPRIN positive area ratio of the difference was significant (P lt;0.05). Conclusions: EMMPRIN expression in thyroid cancer over the occurrence and development play an important role. [Keywords: papillary thyroid carcinoma; EMMPRIN; immunohistochemistry; statistical analysis Thyroid cancer is a common head and neck cancer, occur in women and young patients. Because of its pathological type and more, it is quite different biological behavior. We usually based on tissue origin and differentiation and divided it into four types: papillary carcinoma , follicular carcinoma, medullary carcinoma and undifferentiated carcinoma. and papillary thyroid cancer is the most common malignant tumor, thyroid cancer accounts for about 60% to 70% [1,2], its pathogenesis is not entirely clear, Therefore, to further elucidate the molecular pathogenesis of thyroid cancer, its prevention is of significance. Extracellular matrix metalloproteinase inducer (extracellular matrix matalloprotei