About PTEN survivin in breast basal cell carcinoma-like significance.docVIP

 PAGE \* MERGEFORMAT 7 About PTEN survivin in breast basal cell carcinoma-like significance Of: Wang Qiong LIU Bei Fan Jun He Yujuan [Abstract] Objective: To explore PTEN, survivin in breast basal cell carcinoma samples. Methods: Immunohistochemistry was used to detect the 40 cases of basal cell-like breast cancer surgical specimens in the PTEN, survivin expression, combined with the control group were statistically analysis. Results: PTEN positive expression rate was 40% (16/40), survivin positive expression rate was 72.5% (28/40). Conclusion: PTEN, survivin expression may be associated with the occurrence of basal cell carcinoma, the development of closely related. [Keywords:] breast basal cell carcinoma; PTEN; survivin Breast basal cell carcinoma (basal like subtype breast carcinoma, BLBC) is a gene which is defined by a subtype of breast cancer, Perou [1] that its gene expression profile similar to breast basal / myoepithelial cells. because the gene is more expensive and difficult to promote the diagnosis, now we are more respected that triple-negative with a positive indicator for myoepithelial basal cell carcinoma can be diagnosed. We examined PTEN, survivin in 40 cases of breast carcinoma cells in the basal expression, hoping to increase the basal-like breast cancer diagnosis and prognosis of understanding. 1 Materials and methods 1.1 study God Bless collected Affiliated Hospital of Wuhan University of Technology Department of Pathology, January 1998 ~ December 2008 of 422 surgical cases of invasive breast cancer screening BLBC 40 were selected as samples, aged from 25 to 68 years, the average age of 59.17 years. Replacement of the non- special type of invasive ductal carcinoma of 40 cases as control group 1 and 40 cases of benign breast hyperplasia as control group 2. 1.2 Methods 1.2.1 Immunohistochemistry Immunohistochemistry using two-step Sp. PTEN, survivin monoclonal antibody was purchased from Shanghai Biological Technol