About Xiaoguruanjian pill cirrhotic rat liver histopathology and epidermal growth factor.docVIP

 PAGE \* MERGEFORMAT 13 About Xiaoguruanjian pill cirrhotic rat liver histopathology and epidermal growth factor Of: Qi Zhong Xi Geng blue book, Geng beam Hua, Wang Shaoxian, Wei Xuan [Abstract] Objective To observe Xiaoguruanjian pill cirrhotic rat liver histopathology and epidermal growth factor (EGF). Methods modeling complex factors by carbon tetrachloride cirrhotic rat model, replicated, randomized treatment: the normal group and model group normal saline, Xiaoguruanjian pill low and high dose group were administered daily pill Xiaoguruanjian suspension 1.6 g / kg body weight and 3.2 g / kg body weight, daily irrigation positive drug control group stomach Fufangbiejiarangan piece suspension 0.6 g / kg body weight for 4 weeks. cirrhotic rats observed under light microscope morphological changes in liver and serum and liver EGF levels. Results compared with the normal group, model group, liver stromal extensive fibrous tissue hyperplasia can be divided into the normal lobular liver cell clusters of different sizes (ie, the formation of false lobules), EGF serum and liver tissue was significantly higher (P lt;0.01). with model group compared Xiaoguruanjian pill high and low dose group and the positive control group hepatic lobules also damaged a small amount of fibrous tissue proliferation, but no formation interval. EGF in serum and liver tissue was significantly decreased (P lt;0.05 or P lt;0.01 .) high dose group compared with the positive control group was significantly (P lt;0.05). Conclusion Xiaoguruanjian pill can significantly improve the liver cirrhosis in rats histological damage, and can reduce serum and liver EGF level, has significant anti-liver fibrosis, the role of blocking the process of cirrhosis, the emergence and regression of ascites also have a positive impact. [Keywords:] Xiaoguruanjian pill, liver cirrhosis, pathology, epidermal growth factor, rat Abstract: Objective To observe the effect of Xiaogu Ruanjian pills on hepatic