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Acute pulmonary thromboembolism alteplase emergency thrombolytic therapy observed
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Acute pulmonary thromboembolism alteplase emergency thrombolytic therapy observed
[Abstract] Objective To observe alteplase treatment of pulmonary embolism in clinical outcome. Methods 10 cases of acute massive pulmonary thromboembolism patients, while giving basic treatment given thrombolytic therapy with alteplase, 100 mg, intravenously 2 h, then to enoxaparin 4 000 IU, sc, 1 / 12 h, a total of 7 d, the 4th day of warfarin, 3 ~ 5 mg / d, 2 d continuous monitoring of prothrombin time ( PT), international normalized ratio (INR) of 2.5 (2.0 ~ 3.0), the disabled low molecular weight heparin, warfarin continuously for 6 months. Results 10 patients were cured, 8 cases, 2 cases. All patients without severe bleeding tendency. Conclusions alteplase for acute pulmonary embolism in patients with thrombolytic therapy, safe and effective, fewer side effects, but the need to expand the assessment of clinical observation of samples.
[Keywords:] pulmonary embolism, thrombolytic therapy, alteplase
Pulmonary embolism from the venous system or right heart or pulmonary artery branch occlusion due to thrombus to the pulmonary circulation and respiratory dysfunction as the main clinical and pathophysiological features. Of acute massive thrombosis, thrombolytic therapy is superior to simple anticoagulant. thrombolytic therapy can quickly dissolve clots, pulmonary embolism lifted to restore lung reperfusion, reduced pulmonary resistance, decreased right ventricular preload, reversing right heart failure. thrombolytic therapy not only reduces the large area of patients with pulmonary embolism mortality, but also improve the quality of life and long-term prognosis.
1 Clinical data
1.1 General Information June 2002 ~ February 2009 hospital emergency department treated 10 cases of massive pulmonary embolism patients, 6 males and 4 females, aged from 34 to 65 years, median age 40 years old, onset to the admission time 4 ~ 28 h.
1.2 The inclusion c
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