Ang 2 and VEGF synergy and its anti-tumor angiogenesis therapy of.docVIP

 PAGE \* MERGEFORMAT 12 Ang 2 and VEGF synergy and its anti-tumor angiogenesis therapy of Author: Li-Li Wei Jing Su Hang Xu Gang Abstract tumor angiogenesis is a complex process in which angiopoietin (Ang) family and vascular endothelial growth factor (VEGF) family of coordination is crucial. Ang is the only family with receptor agonists and inhibitors of pro-angiogenic factor, can and endothelial cells of the tyrosine kinase receptor Tie  2 binding to participate in angiogenesis. Tumor cells secrete VEGF, which together Ang  2 to promote angiogenesis. On the structure and the role of VEGF and Ang-depth study of the mechanism will contribute to new and clinical application of anti-angiogenic drug development. In this paper, Ang and its receptor in the structure and mechanism of action, Ang and its receptor in tumor angiogenesis therapy applications, as well as Ang  2 and VEGF synergy mechanisms are reviewed. Keywords: angiopoietin; vascular endothelial growth factor; Angiogenesis Synergism between Ang  2 and VEGF and Its Application of Anti  angiogenesis in Tumor Therapy - Review Abstract Tumor angiogenesis is a complicated process in which VEGF and the members of Ang family have been proposed to play an important role. Ang family is the only vascular growth factor family including activators and inhibitors. They can all bind with specific tyrosine kinase receptor Tie  2 and participate in angiogenesis. Vascular endothelial growth factor (VEGF) is secreted by tumor cells and coordinates with Ang to promote angiogenesis. Further research on the structure and functional mechanism of VEGF and Ang will contribute to develop a new type of antiangiogenesis medicine, which might have good perspect in clinical practice. In this paper, the structure and action mechanism of Ang family and its receptor Tie  2, the application of Ang family and Tie in tumor therapy, and the synergic mechanism between Ang and VEGF were summarized.