Antibiotic Research Glycosyltransferase.docVIP

 PAGE \* MERGEFORMAT 33 Antibiotic Research Glycosyltransferase Author: Huan-qin Wang on behalf of Shuttle Yue-Mao Shen Abstract glycosides antibiotics are widely used clinical anti-bacterial and anti-tumor compounds. These compounds in the body by the glycosyltransferase catalysis, glycosylation biosynthesis of antibiotics is usually the last place, sugar-based location, type and quantity of the antibiotic activity of glycosides have great impact. In this paper, Glycosyltransferase types, functions, characteristics and its application in combinatorial biosynthesis of the application and research prospects. Keywords: antibiotics Glycosyltransferase antibiotic glycosides glycosylation Recent advances in antibiotic glycosyltransferases ABSTRACT Glycoside antibiotics, a category of compounds widely used clinically for anti  bacterial and anti  cancer, are catalyzed by antibiotic glycosyltransferases (Gtfs) in vivo. The sugar moieties are transferred to the corresponding aglycon by Gtfs, often work at very late stages of biosynthesis of antibiotics. The position, type and number of sugar moieties incorporated to the antibiotics have great impact on its bioactivity. This article provides an overview of the categories, functions, characteristics of Gtfs, their applications in combinatorial biosynthesis, and the prospects for research . KEY WORDS Antibiotic glycosyltransferase; Glycoside antibiotics; Glycosylation Glycoside antibiotics in clinical practice is mainly used for anti-bacterial and anti-tumor, in the antibiotic biosynthesis gene cluster has identified a number of Glycosyltransferase encoding gene [1], but there Glycosyltransferase antibiotics (antibiotic glycosyltransferases, Gtfs) of the specificity and catalytic mechanism not know much about. Sugar-based combination with different ligands can greatly increase the structural diversity of natural products, in the function of these sugar components are usuall