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Combined inhalation of bronchial asthma and IgE levels of NO
[Abstract] Objective: To understand the suspension of budesonide and salbutamol inhalation solution combined IgE in asthmatic children and changes in NO levels. Methods: A randomized double-blind controlled study, the asthmatic children were divided into two groups, each 30 cases, including the control group alone salbutamol inhalation solution of 2 to 3 times / d, 10 ~ 15 min / times; the observation group with budesonide suspension + salbutamol solution, add 2 mL normal saline inhalation in the United 2 to 3 times / d, 10 ~ 15 min / times. Results: The plasma total IgE in asthmatic children group level, plasma NO levels in plasma of children with the single drug group total IgE, plasma NO levels, the difference was statistically significant (P lt;0.05). The observation group of clinical symptoms and signs of improvement than the control group. Conclusion: suspension of budesonide and salbutamol inhalation solution combined with a strong and rapid anti-inflammatory effect of the acute asthma attack and may improve the clinical symptoms and decreased plasma total IgE, plasma NO levels.
[Keywords:] bronchial asthma; budesonide suspension; salbutamol solution; IgE; NO
Bronchial asthma (the asthma) the prevalence in the world is rising, especially in children, is a kind of chronic reversible airway obstruction, airway inflammation and airway hyperresponsiveness as the main features of the disease. IgE and Nitric oxide (Nitricoxide, NO) is important information elements, in the pathogenesis of asthma is very important and complex role. In recent years, with suspension of budesonide and salbutamol combined spray the solution on acute attack of asthma treatment, We suspension of budesonide and salbutamol inhalation solution for asthma in children in the United IgE and NO levels in a study are reported below.
1 Materials and Methods
1.1 from June to December 2008, clinic
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