CPA disodium liposomes on rats with severe acute pancreatic injury.docVIP

 PAGE \* MERGEFORMAT 17 CPA disodium liposomes on rats with severe acute pancreatic injury Of: Zhang Yong Chun party wins, sand Xin, Cai Huazhong, Chen Min, Jiang Deli, Zhang Jianxin [Abstract] Objective: To investigate the CPA disodium liposomes (liposomal clodronate) on severe acute pancreatitis (SAP) in rat pancreatic injury. Methods: Preparation of CPA film disodium liposomes. By pancreatic capsule uniform injection of 5% sodium taurocholate production SAP model. SD 48 rats were randomly divided into control group (C group), empty liposome group (P group), disodium liposomes CPA group (T group). P group and T group of rats were made SAP model. tooling 2 h and 6 h after mesenteric vein blood, detection of serum amylase, interleukin 6 (IL 6), Tumor necrosis factor-@ (TNF @) content were observed pathological changes of pancreatic tissue and pancreatic pathological score of pancreas immunohistochemistry the expression of Caspase 3. Results: P rats phenol levels of serum amylase were significantly higher than C increased (P lt;0.01), T group of serum amylase levels were significantly lower than the P group. P group than C group 2,6 h of serum IL 6, TNF @ significantly higher (P lt;0.01), T group than in P rats 2,6 h of serum IL 6, TNF @ levels were significantly lower (P lt;0.01). T group P compared with the pathological changes of pancreas were significantly reduced pancreatic pathological score was significantly lower (P lt;0.01) . pancreas increased Caspase 3 expression. Conclusion: CPA disodium cleared liposomes selectively monocytes / macrophages, on the SAP has a protective effect of pancreatic injury in rats. [Keywords:] severe acute pancreatitis; chloride acid disodium liposomes; macrophages [Abstract] Objective: To investigate the protective effect of lipsomal clodronate against pancreas injury in rats with severe acute pancreatitis (SAP). Methods: Lipsomal clodronate was prepared by means of thin film. The models of SAP were established by