Elderly patients with severe immune purification of rheumatoid arthritis Evaluation of the efficacy and safety of.docVIP

 PAGE \* MERGEFORMAT 10 Elderly patients with severe immune purification of rheumatoid arthritis Evaluation of the efficacy and safety of Of: Mei Lan Zhu Xia Lin Jinying Weimei Qiu Huang Yukui LEE Wing-dare [Abstract] Objective To evaluate the immunological purification of elderly patients with severe rheumatoid arthritis (RA) of the efficacy and safety. Methods 68 patients selected, randomized, experimental group of 36 patients in the control group of 32 patients. Experimental group A while oral immunization purification Ammonia Neopterin and sulfasalazine; the control group were treated with the same dose of methotrexate and sulfasalazine. experimental group and control group after treatment were evaluated 1,12,24 weeks. efficacy was evaluated by American College of Rheumatology Association (ACR) efficacy evaluation ACR20, 50,70. experimental group and control group 1 week after treatment to achieve ACR20 were 39% and 9% (P lt;0.01); 12 weeks after treatment reached ACR20 were 75% and 43% (P lt;0.05), ACR50 were 53% and 28% (P lt;0.05), ACR70 were 30% and 13% (Pgt; 0.05), 24 weeks after treatment 89% achieved ACR20 and 71, respectively % (P lt;0.05), ACR50 were 64% and 37% (P lt;0.05), ACR70 were 39% and 16% (P lt;0.05). adverse reactions 4 cases of the experimental group and control group 3 patients, mild symptoms and the symptomatic improvement. Conclusion immune purification combined with methotrexate and sulfasalazine effective treatment of severe RA were significantly older, significantly better than methotrexate and sulfasalazine, and the rapid onset of more sustained efficacy, safety good. [Keywords:] rheumatoid arthritis; old; immune purification With the aging of our population of elderly rheumatoid arthritis (RA) number of patients showed a gradual upward trend. Elderly RA in clinical manifestations, associated diseases, diagnosis, and treatment with RA in different non-elderly, especially elderly onset RA (EORA) especially, the elderly