Evaluation of the status quo of drug through the blood-brain barrier method.docVIP

 PAGE \* MERGEFORMAT 9 Evaluation of the status quo of drug through the blood-brain barrier method [Abstract] brain barrier blood-brain barrier is the most important part of maintaining the stability of the central nervous system micro-environment, but also limits the majority of drugs into brain tissue of the nervous system diseases, therapeutic effect. Modification of drugs through a variety of ways to enable scientists to enter the brain to become drug-related problems and evaluation of drug through the blood-brain barrier has also become one of the important issue. This paper is divided into object type according to experimental animals in vivo, in vitro brain tissue, in vitro blood-brain barrier model, mathematical model of the four classes Comprehensive Assessment. [Keywords:] blood-brain barrier; drug evaluation; pharmacokinetics Within the central nervous system neurons in the normal function of the activities of the micro-environment surrounding the need to maintain a certain stability, to maintain this stability, the structure of that brain barrier. According to their shape, the brain barrier into three groups: the blood - brain barrier (blood  brain barrier, BBB), blood - brain barrier (blood  cerebrospinalfluid barrier), cerebrospinal fluid - brain barrier (cerebrospinalfluid  brain barrier). Which, BBB for the three most important components. BBB microscopic three-tiered structure, from the inside out were (1) the brain and spinal cord capillary endothelium, unlike the peripheral capillary endothelium is the brain capillary endothelial cell tight junctions between the cells pinocytotic vesicle is very fewer cells are rich in enzyme systems, the role of sub-barrier mechanical barriers and enzyme barriers [1]; (2) capillary basement membrane; (3) glial membrane, which astrocytes foot processes. Substances through the BBB are mainly four ways: directly through the water-soluble small molecules, intercellular diffusion; fat-soluble molecule