Exendin4 in type 2 diabetic rat isletcell proliferation.docVIP

 PAGE \* MERGEFORMAT 14 Exendin4 in type 2 diabetic rat isletcell proliferation [Abstract] Objective To observe Exendin 4 on the chain STZ (STZ) diabetes modeling (DM) rats, fasting blood glucose (FBG), pancreatic islet cell function and the number of rats. Methods SD rats fed high fat combined with low-dose intraperitoneal injection of STZ (35 mg / kg), prepared with type 2 diabetes (T2DM) rats were randomly divided into DM group and Exendin 4 treatment of low, medium and high dose group and normal control group, Exendin 4 administration rats were killed after 6 w, heart blood test FBG, glycosylated hemoglobin (HbA1c), insulin, pancreas tissue sections for HE staining, insulin antibody immunohistochemistry, proliferating cell nuclear antigen staining (PCNA, cell proliferation rate calculated. Results Exendin 4 Expression of various doses of insulin-positive cell proliferation rate in DM group increased (P lt;0.01), Exendin 4 high dose group compared with the DM group, FBG and HbA1c levels were significantly lower (P lt;0.01). Serum insulin increased in the the low dose group but no significant difference between the DM group were significantly different. Conclusions DM Exendin 4 can promote the proliferation of rat pancreatic islet cells, improve blood glucose metabolism and insulin resistance. [Keywords:] Exendin 4, diabetes, pancreatic cells, the proliferation rate Inadequate secretion of insulin and insulin resistance in type 2 diabetes mellitus (T2DM) in the pathogenesis, DM cell number relative or absolute lack of the main reasons for its incidence, the traditional DM treatment by stimulating the secretion of insulin to lower blood sugar, increased -cell affordable, easy to cause -cell failure, therefore, it would promote cell proliferation, providing a fully functional cells, there will be a fundamental treatment of DM. glucagon-like peptide 1 receptor agonists (GLP 1 is near DM decade the field of drug research focus of concern (1,2), a