IL1511 sites and TNF308 polymorphism and non-cardia gastric cancer in Shaanxi Han relations.docVIP

 PAGE \* MERGEFORMAT 18 IL1511 sites and TNF308 polymorphism and non-cardia gastric cancer in Shaanxi Han relations Of: Jia Ai, Gong Jun, Li Premiership, the new Ming Chang, Hao Zhiming, Dong Lei [Abstract] Objective To investigate the proinflammatory cytokine interleukin (IL) 1 gene promoter region of 511 points and tumor necrosis factor-@ (TNF @) 308 polymorphism and non-cardia gastric cancer in Shaanxi Han susceptibility. Methods Polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) method on 106 patients in Shaanxi Han and 108 non-cardia gastric cancer patients with non-ulcer dyspepsia patients (control group) IL 1 promoter sites and 511 TNF @ 308 polymorphism. Results IL 1 gene promoter in 511 genotype CC, CT, TT frequency in gastric cancer group and control group were 12.3%, 54.7%, 33% and 16.7%, 50.9% , 32.4%, no significant difference (Pgt; 0.05). allele C, T frequency in gastric cancer and control groups were 39.6%, 60.4% and 42.1%, 57.9%, and the genotype and allele frequencies In the gastric cancer group and control group were not significantly different (Pgt; 0.05). TNF @ the 308 genotypes GG, GA, AA frequency in gastric cancer and control groups were 90.6%, 1.9%, 7.5% and 84.3%, 12.9%, 2.8%, and allele G, A frequency in gastric cancer and control groups were 91.5%, 8.5% and 85.6%, 14.4%, and the genotype and allele frequencies in gastric cancer group and control There were no significant group differences (Pgt; 0.05). Conclusion IL 1 promoter gene polymorphisms 511 and TNF @ 308 gene polymorphism and non-cardia gastric cancer in Shaanxi Han found no correlation between. [Keywords:] interleukin-1, tumor necrosis factor-@, gene polymorphism, gastric cancer, Han ABSTRACT: Objective To investigate the correlation of the polymorphisms of the IL 1 promoter region 511C / T and tumor necrosis factor @ (TNF @) 308G / A gene with the susceptibility of non cardiac gastric cancer of Shaanxi Chinese population. Methods Th