In spontaneously hypertensive rats serum PCP PNP and the impact of MMP1.docVIP

 PAGE \* MERGEFORMAT 7 In spontaneously hypertensive rats serum PCP PNP and the impact of MMP1 [Abstract] Objective To study in spontaneously hypertensive rats (SHR) serum procollagen type carboxy-terminal peptide (P CP, serum N-terminal procollagen peptide (P NP and serum matrix metalloproteinase 1 (MMP 1 of and its significance. Methods 16 of 12 week old male SHR were randomly divided into 2 groups, n = 8, respectively, and saline to valsartan, and select the 8 weeks of age with male Wistar Kyoto rats (WKY) as a control. administration 8 w post by ELISA, serum P CP, P NP and MMP 1 concentrations. Results SHR control group, serum P CP, P NP were significantly higher than that of WKY group (P lt;0.01); the SHR group of serum P CP, P NP concentration significantly lower than SHR control group (P lt;0.01); SHR treated serum P CP, P NP, MMP 1 levels and WKY group was not significantly different (Pgt; 0.05). Conclusions Valsartan can regulate serum P CP, P NP and MMP 1 content, recovery of extracellular matrix synthesis and degradation of the dynamic balance, inhibit the proliferation of cardiac extracellular matrix, to prevent ventricular remodeling. [Keywords:] valsartan, spontaneously hypertensive rats, serum carboxy-terminal procollagen type peptide, serum amino-terminal procollagen peptide, serum matrix metalloproteinase 1 Essential hypertension (EH) can cause left ventricular hypertrophy (LVH. previous studies mostly focused on LVH in cardiac hypertrophy and its various stimulating factor, but rather on the myocardial interstitial cell proliferation and lead to abnormal accumulation of collagen fibers myocardial fibrosis, and the effects of valsartan in this regard was less than careful research (1), and in clinical, more use of ultrasound and other means to judge roughly the degree of LVH, is still not very accurate to predict the condition of chemical indicators developments. The purpose of this study, valsartan in elderly hypertens