Insulin pump therapy in newly diagnosed type 2 diabetic patients on blood glucose and lipid and plasminogen activity.docVIP

 PAGE \* MERGEFORMAT 14 Insulin pump therapy in newly diagnosed type 2 diabetic patients on blood glucose and lipid and plasminogen activity [Abstract] Objective To observe the insulin pump therapy in patients with newly diagnosed type 2 diabetes 2 weeks before and after the blood glucose, glycated hemoglobin, lipids, fibrinolytic activity and improved insulin resistance. Methods Patients with newly diagnosed type 2 diabetes, 33 cases admitted to hospital before treatment oral glucose tolerance test, fasting blood glucose and postprandial 2 h blood glucose, and glycated hemoglobin, lipids, insulin, tissue plasminogen activator and plasminogen activator inhibitor -1 levels, insulin resistance with Homa-IR said. After two weeks of insulin pump therapy to stop the insulin pump, 2 day trip OGTT test to measure blood sugar, glycosylated hemoglobin, lipids, insulin, tissue plasminogen activator and plasminogen activator inhibitor -1 levels. the result of insulin pump therapy in patients after fasting and postprandial blood glucose to achieve good control (P lt;0.01), glycosylated hemoglobin from baseline (8.6 + -3.1)% to (7.1 + -1.6)%, and no significant low blood sugar. The serum total cholesterol, low density lipoprotein cholesterol, triglycerides decreased significantly compared with before treatment, increased high-density lipoprotein cholesterol, LDL cholesterol before treatment was 3.26 + -0.85 mmoL / L, after treatment was 1.81 + - 0.78 mmoL / L (P lt;0.05), triglyceride before treatment, 2.86 + -0.85 mmoL / L, after treatment 1.92 + -0.64 mmoL / L (P lt;0.01). fibrinolytic activity obtained in a significant improvement after treatment, tissue plasminogen activator from before treatment 0.225 + -0.113 IU / ml increased to 0.457 + -0.177 IU / ml (P lt;0.01), plasminogen activator inhibitor -1 from baseline 0.898 + -0.168 AU / ml / L fell to 0.533 + -0.215 AU / ml (P lt;0.05). insulin resistance index Homa-IR also significantly lower than before treatment, 4.