Intensive insulin therapy in severe traumatic brain injury study.docVIP

 PAGE \* MERGEFORMAT 3 Intensive insulin therapy in severe traumatic brain injury study Author: Huang River, Han-Min Chen, Yu Jin-gang, tube Dingguo, Chen Shaowei [Abstract] Objective To investigate patients with severe head injury Intensive insulin therapy in control of stress hyperglycemia on prognosis. Methods to exclude diabetes and other diseases that directly affect glucose metabolism under the conditions of the 96 cases of severe traumatic brain injury were randomly divided into conventional treatment group and intensive insulin therapy group, two groups were given the slow continuous intravenous insulin pump, intensive insulin therapy group strict control of blood glucose in the 4.4 ~ 6.1 mmol / L; conventional treatment group, blood glucose control in 10.0 ~ 11.11 mmol / L. Results In patients with intensive insulin treatment group, the number of days of insulin use, ventilator days, days of antibiotic use than conventional treatment group (P amp;lt;0.05); nosocomial infection and mortality in the treatment group was better than the control group (P amp;lt;0.05) . The incidence of low blood sugar was no significant difference between the two groups (Pamp;gt; 0.05). Conclusion In patients with severe brain injury, the use of intensive insulin therapy program, can significantly improve patient prognosis. [Keywords:] severe brain injury; intensive insulin therapy; stress hyperglycemia Severe head injury patients experience due to machine a series of complex micro-circulation, neuroendocrine, stress reactions, pathophysiological changes, in turn resulting in high energy consumption, high catabolism and other metabolic disorders. Stress-induced high blood sugar is the body affected by post-traumatic hormonal imbalance in the body caused by reactive hyperglycemia. More than high blood sugar and insulin resistance related to severe head injury patients under stress often accompanied by high blood sugar and some will seriously affect the success rate of re