Ischemia - reperfusion injury and ischemic preconditioning and ischemia-protective effect of post-processing mechanism.docVIP

 PAGE \* MERGEFORMAT 26 Ischemia - reperfusion injury and ischemic preconditioning and ischemia-protective effect of post-processing mechanism Author: MA Jian-Wei Du Council Bo WEN Xiao-Jing Keywords: Ischemia; reperfusion injury; ischemic preconditioning Ischemia is the most common clinical symptoms, especially cardiac ischemic injury has been a large number of academics who have studied and concerns. Past that the short-term reversible myocardial ischemia caused by myocardial injury makes it more difficult to tolerate ischemic injury again. Therefore considered that accumulate multiple transient ischemic inevitable result of myocardial necrosis. 80 years Murry [1] the first time in the dog experiment was found a short coronary ischemia can make the heart through a long-term follow-up to an area of ischemic myocardial infarction when compared to those with a long-term ischemia significantly reduced the size, so make the pre-ischemic processing concept. In 2003, Zhao et al [2] myocardial ischemia-reperfusion in dogs carried out three times before the 30s reperfusion and found that coronary artery endothelial function compared to those with prolonged reperfusion significantly improved, but also obviously myocardial infarct size reduced its level of protection similar to ischemic preconditioning. Therefore proposed the concept of ischemic post-processing. The discovery of both the protection of ischemic myocardium has opened new areas of research. A myocardial ischemia - reperfusion injury 1.1 Myocardial ischemia - reperfusion injury of the concept and the performance of ischemia - reperfusion (ischemia reperfusion, IR) refers to the myocardial ischemia, myocardial metabolism of obstacles, thus there was a series dysfunction; ischemic some time Myocardial blood supply restored, the heart does not always resume its normal function and structure, is conversely increased the performance of myocardial cell injury, namely, the so-called i