2型糖尿病合驳蘑高血压患者血清同型半胱氨酸的变化及意义.pdf

第36卷第 6期 2015年 12月 同济 大学 学 报 (医学 版 ) JOURNAL OF TONGJI UNIVERSITY(MEDICAL SCIENCE) VOl_36 NO．6 Dec．，2015 doi：10．161 8／j．108—0392．2015．06．018 ·临床研究 · 2型糖尿病合并高血压患者血清同型 半胱氨酸的变化及意义 吴 萍，李莹杰，罗 斌 (同济大学附属同济医院营养科，上海 200065) 【摘要】目的 探讨2型糖尿病(T2DM)合并高血压患者血清同型半胱氨酸(Hcy)水平的变化及意义。方法 于 2014年 1月至 2014年 12月在同济大学附属同济医院内分泌科病房收集糖尿病住院患者 527例，根据是否合并高 血压分为单纯 T2DM组和T2DM合并高血压组，调查所有患者的年龄、性别、文化程度、茶、咖啡、烟、酒、锻炼及糖 尿病病程，用酶联免疫吸附法(ELISA)测定患者血清Hcy水平，并对两组指标分析比较。结果 单纯T2DM 组与 T2DM 合并高血压组年龄、性别、文化程度、饮酒、糖尿病病程比较，差异有统计学意义(P0．05)；单纯T2DM 组血 清Hcy水平(11．20±3．83 p~moL／L)低于T2DM合并高血压组Hcy水平(13．69±7．56~mol／L)，差异有统计学意 义(P0．05)；患者 Hcy水平与年龄、糖尿病病程呈明显正相关(r=0．232，P0．001；r=0．112，P=0．010)。结论 T2DM 合并高血压患者血清Hcy水平明显增高，提示高Hcy水平与糖尿病患者血压升高有关，糖尿病患者年龄越 大、糖尿病病程越长，Hcy水平越高，早期监测糖尿病患者的 Hcy水平有利于对糖尿病患者的预后进行评估。 【关键词】2型糖尿病；高血压；同型半胱氨酸 【中图分类号】R 587 【文献标志码】A 【文章编号】1008-0392(2015)06—0099-04 Serum homocysteine level in type 2 diabetic patients complicated with hypertension W Ping，LI Ying-jie，LUO Bin (Dept．of Nutrition，Ton~i Hospital，Ton~i University，Shanghai 200065，China) 【Abstract】Objective To investigate serum homocysteine levels in type 2 diabetic(T2DM)patients complicated with hypertension and its clinical significance．M ethods Five hundred and twenty seven patients with T2DM admi~ed in Department of Endocrinology，Tongji Hospital from January 2014 to December 2014，were enrolled in the study，including 356 cases comp~cated with hypertension and 17 1 cases without hypertension．Age，sex，education levels，tea an d coffee consuming，smoking， alcohol drinking，exercise and duration of diabetes were investigated．The serum homocysteine levels were detected by ELISA method．The indicators of two groups were an alyzed and compared．Result There were significant differences in age，sex，education level，alcohol drinking，duration of diabetes between T2DM group and T2DM with hypertension group(P0．05)．The serum homocysteine level in T2DM group was significant lower than that in T2DM with hypertension group(1 1．20 ± 3．83 i~moVL VS 13．69±7．56 ixmol／L，P0．0