MMP9 COX2 expression in bladder cancer research.doc

 PAGE \* MERGEFORMAT 9 MMP9 COX2 expression in bladder cancer research OF: JM Wood combined force of Abu Thar, Du Chunhui, fertility Xiati I bought Seoul Liaohong Li, Tian Gang [Abstract] Objective To study the bladder urothelial carcinoma (BUC) in the MMP 9, COX 2 expression, to clarify its biological behavior of bladder cancer. Methods using immunohistochemistry in 43 cases of bladder cancer specimens and 10 cases of control group specimens MMP 9, COX 2 expression detected and compared. Results MMP 9 and COX 2 in normal mucosa and the different pathological grade and clinical stage, the positive rate was significantly different (P lt;0.05 or 0.01). MMP 9 and COX 2 in the positive rate of pathological grade and clinical stage significantly increased the rise. MMP 9 and COX 2 expression correlated (P lt;0.01). Conclusions MMP 9 and COX 2 expression close relationship with the biological behavior of BUC for an early understanding of bladder cancer invasion and metastasis help. [Keywords:] bladder cancer; matrix metalloproteinase-9; cyclooxygenase 2; expression Bladder cancer (BC) is the human genitourinary system one of the most common malignant tumor, the incidence rate in the country ranks first in urological malignancies, and the incidence increases every year, second only to prostate cancer in the United States and Europe the second door bit. BC after the age of male to female ratio 5:1,60 high incidence, the average age at diagnosis was 71 years. BC in the bladder urothelial carcinoma (BUC) more than 90%, more than 70% of the BUC after treatment, recurrence About 30% of the tumors appeared to increase the degree of malignancy. superficial BUC recurrence rate of 50% to 70%, and 10% to 15% myometrial invasion and recurrence BUC [1]. Therefore, early diagnosis is an important condition for successful treatment BUC. I detect bladder urothelial carcinoma and normal bladder mucosa of matrix metalloproteinase 9 (MMP 9) and cyclooxygenase 2 (COX 2) expr