Nutmeg extract on mice of the mechanism of microglia.docVIP

 PAGE \* MERGEFORMAT 9 Nutmeg extract on mice of the mechanism of microglia Of: Alice Choi Chun Mao Jiang Meizi love Li Li [Abstract] Objective To investigate the nutmeg extract on mouse BV2 microglial cells of the antioxidant and neuroprotective effect. Methods WST 8 kit and western blotting, we observed nutmeg extract of in vitro rat small plastic BV2 the survival rate of change of interstitial cells and lipopolysaccharide (LPS-induced inducible nitric oxide synthase (iNOS expression. Results nutmeg extract on BV2 cell non-toxic, and inhibited the cytotoxic effect of glutamate and lipid polysaccharide-induced iNOS expression, and the LPS group was significantly different between (P lt;0.05. Conclusion nutmeg extract in vitro on mouse BV2 microglial cells of antioxidant and neuroprotective effect, with good development potential. [Keywords:] nutmeg extract, microglia, anti-oxidative, neuroprotective Alzheimer’s disease (Alzheimer `s disease, AD is a kind of progressive cognitive impairment and memory deficits of the central nervous system degenerative diseases based. AD is one of the key features of brain inflammation, amyloid deposition, activation of microglia induced inflammatory response is the core of the pathological mechanism (1,2). Epidemiologic studies have shown that prolonged application of non-steroidal anti-inflammatory drugs can reduce the risk of suffering from AD, slow the disease, improve symptoms awareness of the seriousness of diminished capacity and delay (3), but as an inhibitor of cyclooxygenase-1 easily lead to gastrointestinal bleeding, liver and kidney toxicity, long-term use, have a certain degree of risk. nutmeg methanol Extract from the Myristicaceae plant tall trees (Myristica fragrans extract natural ingredients, can inhibit the LPS (lipopolysaccharide, LPS induced rat brain microglia activation and spatial learning and memory impairment (4). microglia as immune cells within the central nervous system, has become the