Oxymatrine of serum in patients with chronic renal TGF-1 and the impact of Col.doc

 PAGE \* MERGEFORMAT 12 Oxymatrine of serum in patients with chronic renal TGF-1 and the impact of Col Of: Liao Tingting Yao steel refining, Zhou Lin, Yuan Haozheng, such as Lee, Gui Baosong [Abstract] Objective oxymatrine on chronic kidney disease (CKD) in patients with serum transforming growth factor - 1 (TGF-1), collagen (Col ) the impact of the renal interstitial fibrosis in the development process The role and therapeutic value. Methods 10 patients with healthy controls, 40 patients with chronic kidney disease, according to glomerular filtration rate (GFR) is divided into groups with mild renal impairment (GFR lt;90 mL / min 1.73m2, CKD ), moderate and severe renal injury group (GFR lt;60 mL / min 1.73m2, CKD ), re-stratified random sampling, divided into the conventional treatment group and oxymatrine group. using double antibody sandwich ELISA test, respectively, treatment of the study, serum TGF-1, Col content, two groups were compared using t test TGF-1, Col level differences. Results Oxymatrine group TGF-1, Col was significantly lower than the conventional therapy group (P lt;0.05). Oxymatrine possibly through reduced TGF-1, Col levels, reducing ECM deposits to achieve the prevention of renal interstitial fibrosis. [Keywords:] transforming growth factor - 1 (TGF-1), collagen (Col ), chronic kidney disease, renal interstitial fibrosis, oxymatrine ABSTRACT: Objective To study the effects of oxymatrine on serum TGF-1 and Col levels in patients with chronic kidney disease (CKD) and illuminate the mechanism of renal interstitial fibrosis and treatment. Methods Totally 40 patients were divided into 2 groups according to GFR level : CKD group and CKD group. Then each group was divided into 2 subgroups stratifiedly and randomly: conventional group and oxymatrine group. ELISA was employed to measure TGF-1 and Col activities in the plasma samples of 40 CKD patients and 10 control subjects. Results The levels of TGF-1 and Col were high