Package contains methotrexate Poly lactide lactide Nanoparticles and in vitro release mechanism.docVIP

 PAGE \* MERGEFORMAT 8 Package contains methotrexate Poly lactide lactide Nanoparticles and in vitro release mechanism On: Zheng Mingbin, Ping Gong, Yang Xuemei, Wuxi Ren, Mei Jun [Abstract] Objective To prepare the package containing methotrexate (MTX’s Poly lactide glycolide (PLGA nanoparticles and to study the in vitro drug release mechanism. Methods package prepared by solvent evaporation of PLGA nanoparticles containing MTX, its morphology size were characterized by determination of in vitro release curve, and fitting the model using pharmacy. Results The average particle size of nanoparticles 175.9nm, has a role in sustained, biphasic release behavior of the most dynamic equation. Conclusions of the study MTX for the development of new dosage forms provide an experimental basis. [Keywords:] methotrexate, Poly lactide lactide, nano-particles, fitting Abstract: ObjectiveTo prepare methotrexate (MTX) loaded poly (lactic-co-glycolic) (PLGA) nanoparticles and investigate the mechanism on release in vitro.MethodsMTX-loaded nanoparticles were prepared by emulsion solvent evaporation method. The morphology and size of nanoparticles were studied , and in vitro release curve was measured. Moreover, the release data were fitted with different mathematical models. ResultsThe mean size of nanoparticleas was 175.9nm, and the obtained nanoparticles showed evidently sustained release effect. The release behavior of MTX loaded nanoparticles was well fitted to the double phase dynamic equation.ConclusionThe work provides an experiment basis for the development of novel ideal administration of MTX. Keywords:: Methotrexate; Poly (lactic-co-glycolic); Nanoparticles; Fit Methotrexate (MTX is an antimetabolite class of anticancer drugs on breast cancer, acute leukemia, osteosarcoma, and so has a significant effect, but the cells are caused by decreased bone marrow suppression, liver and kidney damage and other side effects, even endanger the lives of patient