Piperazine estrone in growing ovariectomized mice tibia histomorphometry of bone.doc

 PAGE \* MERGEFORMAT 16 Piperazine estrone in growing ovariectomized mice tibia histomorphometry of bone [Abstract] Objective piperazine estrone (piperazinyl estrone, PE) in ovariectomized mice tibial cancellous bone and cortical bone mass, and to explore its mechanism. Methods 70 Kunming female mice 6 weeks old were randomly divided into 7 groups: based control group (Base group), sham operation group (Sham group), Ovariectomized group (Ovx group), OVX + piperazine estrone low dose group (PE 1 group), OVX + piperazine estrone in the dose group (PE 2 group), OVX + piperazine estrone high dose group (PE 3 groups), OVX + estrone group (E group ), continuous intragastric administration of 42d. experimental mice were killed after a left tibia, the middle of undecalcified bone production, bone histomorphometry parameters were measured. The results can piperazine estrone in ovariectomized mouse tibia Song increased bone mass, decreased trabecular separation, bone formation and resorption decreased. with the Ovx group, PE 2 group and is the best increase cancellous bone, trabecular separation, mild inhibition bone turnover; piperazine estrone on tibial cortical bone of the middle membrane surface to promote bone formation, inhibition of intimal surface of bone resorption, but the effect was not significant. Conclusion piperazine estrone in the dose group (1.0 mg kg-1 d-1) by slightly reducing bone turnover, can effectively prevent cancellous bone in ovariectomized mice bone loss, no obvious effect on cortical bone. [Keywords:] piperazine estrone; osteoporosis; to the ovary; Bone histomorphometry; mice Osteoporosis in the elderly has become a serious threat to major health problems, osteoporosis in postmenopausal women, the incidence rate of 50%, the main cause of impaired ovarian function after menopause, decreased estrogen levels caused by bone loss. Estrogen replacement therapy (Estrogen Replacement Therapy, ERT) for the prevention of postmenopausa