Radix Astragali in alkaline solution to improve the process of astragaloside_0.doc

Radix Astragali in alkaline solution to improve the process of astragaloside Of: Zhang, Zhou Jing, Song Huiqin, Wu Zhili [Abstract] Objective To improve the alkaline solution Astragaloside Radix Astragali the optimum yield. Methods Astragaloside yield the indexes, the use of orthogonal Astragaloside optimal extraction process. Exploring NaOH concentration, hydrolysis time and solid to liquid ratio on the yield of Astragaloside by high performance liquid chromatography - evaporative light scattering method (HPLC-ELSD) content was determined. Results NaOH solution concentration on the yield of Astragaloside play a major role in optimal conditions: NaOH solution concentration of 0.100 mol · L-1, room temperature for hydrolysis of 2 h, and Radix Astragali liquid alkali solution ratio of 1:12, about the content of astragaloside is not group by alkaline hydrolysis of 16.4 times. Conclusion alkaline solution of Radix Astragali can significantly improve the content of Astragaloside. method is simple, practical value, provided the basis for industrial production. [Keywords:] alkaline hydrolysis; astragalus; astragaloside; orthogonal test Mongolia for the legume Astragalus Astragalus Astragalus membranaceus (Fisch.) Bge. Var. Mongholicus (Bge.) Hsiao or Astragalus membranaceus and Astragalus membranaceus (Fisch.) Bge dry root. Astragalus Astragalus saponin is one of the primary efficacy substances, Astragalus Astragalus saponins are mostly soap ring alcohol as aglycone saponin, astragaloside (astragaloside Ⅳ) as its main component [1], often Radix Astragali and its preparations as the quality control of quantitative indicators. pharmacological studies have shown that astragalus A cardiac glycosides with cardiac care, protect the nervous system and endothelial barrier function, improve blood rheology, regulate immune function, anti-aging, anti-gastric ulcer and other functions, in addition to lower blood pressure, sedation, and promote insulin secretion and so on [2