β受体阻滞剂在PCI中的应用讲述.pptx

β受体阻滞剂在PCI术的应用;免责声明;提 纲;药理学及作用机制;心率增快增加冠心病患者的风险！;The effect of heart rate on local haemodynamic forces on the endothelium.;Impact of Left Ventricular Ejection Fraction on Clinical Outcomes Over Five Years After Infarct-Related Coronary Artery Recanalization (from the Occluded Artery Trial [OAT]);β阻滞剂在急性心肌梗死的应用;β阻滞剂在慢性稳定性心绞痛的应用;Heart Rate as an Independent Prognostic Risk Factor in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention;β阻滞剂在心肌梗塞后二级预防的应用;β阻滞剂在非ST段抬高ACS的应用;实践与指南的差距：β阻滞剂在中国冠心病患者中使用现状; β受体阻滞剂在PCI围手术期的应用;β受体阻断剂在非心脏手术期间的使用一直受到重视!;但是在PCI围手术期间的使用？;β受体阻断剂在PCI围手术期间的使用;PCI术前使用β阻滞剂渐少术后CK-MB的上升;术前使用β阻滞剂对AMI PCI术后临床预后的影响;AMI PCI术前静注β阻滞剂提高术后生存率;RABBIT II 研究;急性心肌梗塞PCI术后使用β阻滞剂对临床预后的影响;急性心肌梗塞PCI术后使用β阻滞剂对临床预后的影响;PCI术后使用β阻滞剂渐少一年死亡率;Am Heart J 2003;145:875-81;Conclusions -Adrenergic receptor blockers prescribed after PCI reduced the risk of clinical restenosis, target lesion restenosis, and MACE in this cohort of 4840 patients. The mechanism by which -blockers conferred a protective effect against restenosis remains to be determined. (Am Heart J 2003;145:875-81.);围PCI期间使用β受体阻断剂基于以下几个方面;These findings suggest that metoprolol could inhibit the development of atherosclerosis and stabilize vulnerable plaque by regulation of lipid and reduction of inflammation, in which the change from low shear stress to physiological shear stress around plaque may play an important role.;Conclusions: The intravenous administration of metoprolol before coronary reperfusion results in larger myocardial salvage than its oral administration initiated early after reperfusion. If confirmed in the clinical setting, the timing and route of β-blocker initiation could be revisited.;问题是： β受体阻断剂的使用远远不足！;Use of β-blockers and effects on heart rate and blood pressure post-acute coronary syndromes: Are we on target?;小 结;