Association of Structural Global Brain Network Properties with Intelligence in Normal Aging.docVIP

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Association of Structural Global Brain Network Properties with Intelligence in Normal Aging.doc

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Association of Structural Global Brain Network Properties with Intelligence in Normal Aging

AssociationofStructuralGlobalBrainNetwork PropertieswithIntelligenceinNormalAging FlorianU.Fischer*,DominikWolf,ArminScheurich,AndreasFellgiebel DepartmentofPsychiatryandPsychotherapy,UniversityMedicalCenterMainz,Mainz,Germany Abstract Higher general intelligence attenuates age-associated cognitive decline and the risk of dementia. Thus, intelligence has beenassociatedwithcognitivereserveorresilienceinnormalaging.Neurophysiologically,intelligenceisconsideredasa complex capacity that is dependent on a global cognitive network rather than isolated brain areas. An association of structuralaswellasfunctionalbrainnetworkcharacteristicswithintelligencehasalreadybeenreportedinyoungadults.We investigatedtherelationshipbetweenglobalstructuralbrainnetworkproperties,generalintelligenceandageinagroupof 43cognitivelyhealthyelderly,age60–85years.Individualswereassessedcross-sectionallyusingWechslerAdultIntelligence Scale-Revised (WAIS-R) and diffusion-tensor imaging. Structural brain networks were reconstructed individually using deterministic tractography, global network properties (global efficiency, mean shortest path length, and clustering coefficient) were determined by graph theory and correlated to intelligence scores within both age groups. Network propertiesweresignificantlycorrelatedtoage,whereasnosignificantcorrelationtoWAIS-Rwasobserved.However,ina subgroupof15individualsaged75andabove,thenetworkpropertiesweresignificantlycorrelatedtoWAIS-R.Ourfindings suggest that general intelligence and global properties of structural brain networks may not be generally associated in cognitivelyhealthyelderly.However,weprovidefirstevidenceofanassociationbetweenglobalstructuralbrainnetwork properties and general intelligence in advanced elderly. Intelligence might be affected by age-associated network deterioration only if a certain threshold of structural degeneration is exceeded. Thus, age-associated brain structural changesseemtobepartiallycompensatedbythenetworkandtherangeofth