Atad3 Function Is Essential for Early Post-Implantation Development in the Mouse.docVIP

下载本文档

5
0
约5.45万字
约 12页
2017-05-07 发布于上海
举报
版权申诉

Atad3 Function Is Essential for Early Post-Implantation Development in the Mouse.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Atad3 Function Is Essential for Early Post-Implantation Development in the Mouse

Atad3FunctionIsEssentialforEarlyPost-Implantation DevelopmentintheMouse TobiasGoller1,UrsulaK.Seibold2,ElisabethKremmer3,WolfgangVoos2,WaldemarKolanus1* 1LIMESInstitute,ProgramUnitMolecularCellandImmuneBiology,UniversityofBonn,Bonn,Germany,2InstituteforBiochemistryandMolecularBiology,Universityof Bonn,Bonn,Germany,3HelmholtzCenterMunich,GermanResearchCenterforEnvironmentalHealth,InstituteforMolecularImmunology,Munich,Germany Abstract ThemitochondrialAAA+-ATPaseATAD3isimplicatedintheregulationofmitochondrialandERdynamicsandwasshownto benecessaryforlarvaldevelopmentinCaenorhabditiselegans.InordertoelucidatetherelevanceofATAD3formammalian development, the phenotype of an Atad3 deficient mouse line was analyzed. Atad3 deficient embryos die around embryonicdayE7.5duetogrowthretardationandadefectivedevelopmentofthetrophoblastlineageimmediatelyafter implantation into the uterus. This indicates an essential function of Atad3 for the progression of the first steps of post- implantation development at a time point when mitochondrial biogenesis and ATP production by oxidative phosphorylation are required. Therefore, murine Atad3 plays an important role in the biogenesis of mitochondria in trophoblaststemcellsandindifferentiatingtrophoblasts.Atthebiochemicallevel,wereportherethatATAD3ispresentin five native mitochondrial protein complexes of different sizes, indicating complex roles of the protein in mitochondrial architectureandfunction. Citation:GollerT,SeiboldUK,KremmerE,VoosW,KolanusW(2013)Atad3FunctionIsEssentialforEarlyPost-ImplantationDevelopmentintheMouse.PLoS ONE8(1):e54799.doi:10.1371/journal.pone.0054799 Editor:JenniferNichols,WellcomeTrustCentreforStemCellResearch,UnitedKingdom ReceivedFebruary16,2012;AcceptedDecember17,2012;PublishedJanuary25,2013 Copyright: ? 2013 Goller etal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedthe