Cerebral Hemodynamics and Systemic Endothelial Function Are Already Impaired in Well-Controlled Type 2 Diabetic Patients, with Short-Term Disease.docVIP
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Cerebral Hemodynamics and Systemic Endothelial Function Are Already Impaired in Well-Controlled Type 2 Diabetic Patients, with Short-Term Disease
CerebralHemodynamicsandSystemicEndothelial
FunctionAreAlreadyImpairedinWell-ControlledType2
DiabeticPatients,withShort-TermDisease
PaolaPalazzo1,2*.,PaolaMaggio1.,RiccardoAltavilla1,AlessandraDiFlaviani3,IlariaGiordani3,
IlariaMalandrucco3,FabianaPicconi3,FrancescoPassarelli2,PatrizioPasqualetti4,MatildeErcolani2,
FabrizioVernieri1,SimonaFrontoni3
1Department of Neurology, Campus Bio-Medico University, Rome, Italy, 2Department of Neurology, S. Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy,
3Endocrinology, Diabetes and Metabolism, S. Giovanni Calibita Fatebenefratelli Hospital, University of Rome Tor Vergata, Rome, Italy, 4SeSMIT, Service for Medical
StatisticsIT,FatebenefratelliAssociationforResearch,IsolaTiberina,Rome,Italy
Abstract
Objective: Impaired cerebral vasomotor reactivity (VMR) and flow-mediated dilation (FMD) were found in selected
subgroups of type 2 diabetes mellitus (T2DM) patients with long-term disease. Our study aimed to evaluate cerebral
hemodynamics, systemic endothelial function and sympatho-vagal balance in a selected population of well-controlled
T2DMpatientswithshort-termdiseaseandwithoutcardiacautonomicneuropathy(CAN).
Research Design and Methods: Twenty-six T2DM patients with short-term (4.4064.80 years) and well-controlled
(HbA1C=6.7161.29%) disease, without any complications, treated with diet and/or metformin, were consecutively
recruited.Eighteencontrols,comparablebysexandage,wereenrolledalso.
Results:FMDandshearrateFMDwerefoundtobereducedinT2DMsubjectswithshort-termdisease(8.5%SD3.5and2.5
SD1.3,respectively)comparedtocontrols(15.4%SD4.1and3.5SD1.4;p,.001andp,.05).T2DMpatientsalsodisplayed
reducedVMRvaluesthancontrols(39.4%SD12.4vs51.7%,SD15.5;p,.05).Sympatho-vagalbalancewasnotdifferentin
T2DMpatientscomparedtohealthysubjects.FMDandshearrateFMDdidnotcorrelatewithVMRinT2DMpatientsorin
controls(p..05).
Conclusions: In well-controlledT2DM patients withshort-term disease cerebral hemodynamics and systemic endothelial
functiona
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