Circulating microRNA Profiling Identies a Subset of Metastatic Prostate Cancer Patients with Evidence of Cancer-Associated Hypoxia.docVIP

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Circulating microRNA Profiling Identies a Subset of Metastatic Prostate Cancer Patients with Evidence of Cancer-Associated Hypoxia.doc

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Circulating microRNA Profiling Identies a Subset of Metastatic Prostate Cancer Patients with Evidence of Cancer-Associated Hypoxia

CirculatingmicroRNAProfilingIdentifiesaSubsetof MetastaticProstateCancerPatientswithEvidenceof Cancer-AssociatedHypoxia HeatherH.Cheng1,2.,PatrickS.Mitchell3.¤a,EvanM.Kroh3,AlexanderE.Dowell4,LislyChe′ry4, JavedSiddiqui5,6,PeterS.Nelson1,2,3,RobertL.Vessella4,7,BeatriceS.Knudsen8¤b , ArulM.Chinnaiyan5,9,10,KennethJ.Pienta11,ColmMorrissey4,MuneeshTewari1,2,3,8* 1ClinicalResearchDivision,FredHutchinsonCancerResearchCenter,Seattle,Washington,UnitedStatesofAmerica,2DepartmentofMedicine,UniversityofWashington, Seattle, Washington, United States of America, 3Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 4DepartmentofUrology,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,5MichiganCenterforTranslationalPathology,UniversityofMichigan MedicalSchool,AnnArbor,Michigan,UnitedStatesofAmerica,6DepartmentofPathology,UniversityofMichiganMedicalSchool,AnnArbor,Michigan,UnitedStatesof America, 7Department of Veterans Affairs Medical Center, Seattle, Washington, United States of America, 8Public Health Sciences Division, Fred Hutchinson Cancer ResearchCenter,Seattle,Washington,UnitedStatesofAmerica,9DepartmentofUrology,UniversityofMichiganMedicalSchool,AnnArbor,Michigan,UnitedStatesof America,10BioinformaticsProgram,UniversityofMichiganMedicalSchool,AnnArbor,Michigan,UnitedStatesofAmerica,11DepartmentsofUrology,Oncologyand PharmacologyandMolecularSciences,JohnsHopkinsHospital,Baltimore,Maryland,UnitedStatesofAmerica Abstract MicroRNAs(miRNAs)aresmall(,22nucleotide)non-codingRNAsthatregulateamyriadofbiologicalprocessesandare frequently dysregulated in cancer. Cancer-associated microRNAs have been detected in serum and plasma and hold promiseasminimallyinvasivecancerbiomarkers,potentiallyforassessingdiseasecharacteristicsinpatientswithmetastatic diseasethatisdifficulttobiopsy.HereweusedmiRNAprofilingtoidentifycancer-associatedmiRNAsthataredifferentially expressed in sera from patients with metastatic cast