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The WTXAMER1 gene family evolution, signature and function 英文论文文献
Boutetetal.BMCEvolutionaryBiology2010,10:280
/1471-2148/10/280
RESEARCH ARTICLE
OpenAccess
TheWTX/AMER1genefamily:evolution,
signatureandfunction
AgnèsBoutet1,2,GlendaComai1,2,AndreasSchedl1,2*
Abstract
Background:WTXisanovelgenemutatedinaproportionofWilms’tumorsandinpatientssufferingfrom
sclerosingbonedysplasia.OnthemolecularlevelWTXhasbeenshowntoactasanantagonistofcanonicalWnt/b-
cateninsignalinginfishandmammalsthuslinkingittoanessentialpathwayinvolvedinnormaldevelopmentand
cancerformation.Interestingly,WTXseemstoalsolocalizetoanintranuclearcomponentcalledparaspeckles.Inspite
ofthegrowing
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