Thermodynamic modeling of transcription sensitivity analysis differentiates biological mechanism from mathematical model-induced effects 英文论文文献.docVIP

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Thermodynamic modeling of transcription sensitivity analysis differentiates biological mechanism from mathematical model-induced effects 英文论文文献.doc

Thermodynamic modeling of transcription sensitivity analysis differentiates biological mechanism from mathematical model-induced effects 英文论文文献

Dreschetal.BMCSystemsBiology2010,4:142 /1752-0509/4/142 RESEARCH ARTICLE OpenAccess Thermodynamicmodelingoftranscription: sensitivityanalysisdifferentiatesbiological mechanismfrommathematicalmodel-induced effects JacquelineMDresch1,XiaozhouLiu2,DavidNArnosti2*,AhmetAy3,4* Abstract Background:Quantitativemodelsofgeneexpressiongenerateparametervaluesthatcanshedlightonbiological featuressuchastranscriptionfactoractivity,cooperativity,andlocaleffectsofrepressors.Animportantelementin suchinvestigationsissensitivityanalysis,whichdetermineshowstronglyamodel’soutputreactstovariationsin parameterval

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Thermodynamic modeling of transcription sensitivity analysis differentiates biological mechanism from mathematical model-induced effects 英文论文文献.docVIP