UOGJournalClubAugust2015.PDF

UOG Journal Club: August 2015 胎盘生长因子和超声参数来预测耻骨联合-宫底高度（SFH） 降低的孕妇分娩小于胎龄儿（SAG）的诊断准确性 M Griffin, PT Seed, L Webster, J Myers, L Mackillop, N Simpson, D Anumba, A Khalil, M Denbow, A Sau, K Hinshaw, P Von Dadelszen, S Benton, J Girling, CWG Redman, LC Chappell and AH Shennan Volume 46, Issue 2, Date: August (pages 182– 190) Journal Club slides prepared by Dr Shireen Meher (UOG Editor for Trainees) PlGF to predict SGA Griffin et al., UOG 2015 Introduction • Identifying small-for-gestational-age (SGA) infants is challenging in the low-risk population, as it relies on imprecise techniques such as symphysis–fundus height (SFH) measurement. • 在低危人群中鉴别胎儿小于胎龄（SGA）是一项挑战，因为SGA诊断是建立在 不精准技术的基础上，如：耻骨联合-宫底高度（SFH） • UK guidelines do not advocate routine ultrasound in the third trimester as a screening tool for SGA because of poor predictive value (sensitivity, 38–51%) and no evidence of improved neonatal outcome. • 英国指南不提倡把常规超声作为孕晚期SGA的诊断工具，因为超声的预测价值低 （敏感性，38-51％），且没有证据表明超声技术能改善新生儿结局。 • As placental insufficiency is causative in many cases of growth restriction, markers of placental function could provide adjuncts to currently used methods. • 由于胎盘功能不全是许多胎儿发育迟缓的致病因素，因此胎盘功能的指标能 够为目前的诊断方法带来借鉴意义。 • Previous studies have shown that low levels of maternal serum placental growth factor (PlGF) can distinguish placental SGA from constitutionally small fetuses . • 目前研究表明孕妇血清低水平的胎盘生长因子（PIGF）可以从本质上鉴别胎 盘源性的小于胎龄儿（SGA）。 PlGF to predict SGA Griffin et al., UOG 2015 Aim of the study 研究目标 To assess the diagnostic accuracy of PlGF levels and ultrasound parameters to predict delivery of a small-for- gestational-age infant in women pres