Who is in the drivers seat in 8p12 amplifications ZNF703 in luminal B breast tumors 英文论文文献.docVIP

Bazarov and Yaswen Breast Cancer Research 2011,13:308 /content/13/3/308 VIEWPOINT Who is in the driver’s seat in 8p12 ampli? cations? ZNF703 in luminal B breast tumors Alexey V Bazarov and Paul Yaswen * 1,2 2 Until now, however, the identity of the driver oncogene within this group remained elusive. Abstract Two recent reports identifyZNF703 as an oncogene driving selection of frequent chromosome 8p12 ampli?cations in luminal B breast tumors. The estrogen- responsiveZNF703 gene encodes a transcriptional cofactor that, when overexpressed