Fatal Sepsis Due to Stenotrophomonas Maltophilia in Stem Cell Recipient – Case Report.docVIP

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Fatal Sepsis Due to Stenotrophomonas Maltophilia in Stem Cell Recipient – Case Report.doc

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Fatal Sepsis Due to Stenotrophomonas Maltophilia in Stem Cell Recipient – Case Report

Case Report Macedonian Journal of Medical Sciences. 2011 Dec 15; 4(4):408-410. /10.3889/MJMS.1857-5773.2011.0194 Case Report OPEN?ACCESS Fatal Sepsis Due to Stenotrophomonas Maltophilia in Stem Cell Recipient – Case Report Zlate Stojanoski University Clinic of Hematology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia Abstract Citation: Stenotrophomonas Recipient – Case Report. Maced J Med Sci. 2011 Dec 15; 4(4):408-410. /10.3889/ MJMS.1957-5773.2011.0194. Stojanoski Maltophilia Z. Fatal Sepsis Due Cell to Background: Infections are frequent cause of further morbidity and mortality in stem cells recipients. Infection-related mortality is mainly due to severe bacterial sepsis, pneumonia and fungal infections. in Stem Case Report: We report a 60 years old patient with AML. In the complete remission he is received high- dose chemotherapy followed by autologous peripheral blood stem cell transplantation. The patient was treated in sterile room, conditioned with HEPA filters. Antibiotic prophylaxis regimen consisted Ciprofloxacin 1.0 gr/day, Itraconazol 400 mg/day, Acyclovir 1500 mg/day, and Immunoglobulins IV 0.1 Key words: infective; complications; stem; cell; transplantation. Correspondence:Dr.ZlateStojanoski.University mg/kg once per week. From day +5 patient became febrile (Ne0.5 x 10 /mL). First line antibiotic 3 Clinic of Hematology, Faculty of Medicine, University Republic stojanoskiza@.mk “Ss Cyril of and Macedonia. Methodius”, Skopje, E-mail: regimen consisted third-generation anti-pseudomonal cephalosporine and amynoglicoside during a 72 h, but with no response. As a second line antibiotic therapy was introduced Vancomicyn 2.0 gr/day. On day +10 from blood culture and urine culture was isolated Stenotrophomonas maltophillia with in vitro succeptibilities only to Ciprofloxacin (+3). Co-trimoxasole and again Ciprofloxacin in maximal doses was administered, but patient deteriorate, and in seps