A Tail-like Assembly at the Portal Vertex in Intact Herpes Simplex Type-1 Virions 英文参考文献.docVIP

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A Tail-like Assembly at the Portal Vertex in Intact Herpes Simplex Type-1 Virions 英文参考文献.doc

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A Tail-like Assembly at the Portal Vertex in Intact Herpes Simplex Type-1 Virions 英文参考文献

ATail-likeAssemblyatthePortalVertexinIntactHerpes SimplexType-1Virions MichaelF.Schmid1,CoreyW.Hecksel1,2,RyanH.Rochat1,3,DavidBhella4,WahChiu1,2,3*,FrazerJ.Rixon4 1NationalCenterforMacromolecularImaging,VernaandMarrsMcleanDepartmentofBiochemistryandMolecularBiology,BaylorCollegeofMedicine,Houston,Texas, United States of America, 2Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, 3Graduate PrograminStructuralandComputationalBiologyandMolecularBiophysics,BaylorCollegeofMedicine,Houston,Texas,UnitedStatesofAmerica,4MRC-Universityof GlasgowCentreforVirusResearch,Glasgow,UnitedKingdom Abstract Herpes viruses are prevalent and well characterized human pathogens. Despite extensive study, much remains to be learnedaboutthestructureofthegenomepackagingandreleasemachineryinthecapsidsoftheselargeandcomplex double-stranded DNA viruses. However, such machinery is well characterized in tailed bacteriophage, which share a commonevolutionaryoriginwithherpesvirus.Intailedbacteriophage,thegenomeexitsfromthevirusparticlethrougha portalandistransferredintothehostcellbyacomplexapparatus(i.e.thetail)locatedattheportalvertex.Hereweuse electroncryo-tomographyofhumanherpessimplextype-1(HSV-1)virionstorevealapreviouslyunsuspectedfeatureatthe portal vertex, which extends across the HSV-1 tegument layer to form a connection between the capsid and the viral membrane. The location of this assembly suggests that it plays a role in genome release into the nucleus and is also importantforvirionarchitecture. Citation:SchmidMF,HeckselCW,RochatRH,BhellaD,ChiuW,etal.(2012)ATail-likeAssemblyatthePortalVertexinIntactHerpesSimplexType-1Virions.PLoS Pathog8(10):e1002961.doi:10.1371/journal.ppat.1002961 Editor:JoelD.Baines,CornellUniversity,UnitedStatesofAmerica ReceivedMay9,2012;AcceptedAugust27,2012;PublishedOctober4,2012 Copyright: ? 2012 Schmid et al. This is an open-access article distributed under the terms of the Creative Commo