abd-A Regulation by the iab-8 Noncoding RNA 英文参考文献.docVIP

abd-A Regulation by the iab-8 Noncoding RNA 英文参考文献.doc

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abd-A Regulation by the iab-8 Noncoding RNA 英文参考文献

abd-ARegulationbytheiab-8NoncodingRNA MaheshwarGummalla1,RobertK.Maeda1,JavierJ.CastroAlvarez1,HenrikGyurkovics2, SwethaSingari3,KevinA.Edwards3,Franc?oisKarch1*,WelcomeBender4* 1Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland, 2Institute of Genetics, Biological Research Center, Szeged, Hungary, 3School of BiologicalSciences,IllinoisStateUniversity,Normal,Illinois,UnitedStatesofAmerica,4DepartmentofBiologicalChemistryandMolecularPharmacology,HarvardMedical School,Boston,Massachusetts,UnitedStatesofAmerica Abstract ThehomeoticgenesinDrosophilamelanogasterarealignedonthechromosomeintheorderofthebodysegmentsthat theyaffect.Thegenesaffectingthemoreposteriorsegmentsrepressthemoreanteriorgenes.Thisposteriordominance rulemustbequalifiedinthecaseofabdominal-A(abd-A)repressionbyAbdominal-B(Abd-B).AnimalslackingAbd-Bshow ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repressionintheseneuronalcellsisaccomplishedbya92kbnoncodingRNA.This‘‘iab-8RNA’’producesamicroRNAto repressabd-A,butalsohasasecond,redundantrepressionmechanismthatactsonly‘‘incis.’’Transcriptionalinterference withtheabd-Apromoteristhemostlikelymechanism. Citation: Gummalla M, Maeda RK, Castro Alvarez JJ, Gyurkovics H, Singari S, et al. (2012) abd-A Regulation by the iab-8 Noncoding RNA. PLoS Genet 8(5): e1002720.doi:10.1371/journal.pgen.1002720 Editor:NorbertPerrimon,HarvardMedicalSchool,HowardHughesMedicalInstitute,UnitedStatesofAmerica ReceivedNovember14,2011;AcceptedApril3,2012;PublishedMay24,2012 Copyright: ? 2012 Gummalla et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyagrantfromOtkatoHG;agrantfromtheNationalInstitutesofHealthtoKAE;grantsfromtheSwissNationalFundfor Research,theNCCRFrontiersinGenetics

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