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abd-A Regulation by the iab-8 Noncoding RNA 英文参考文献
abd-ARegulationbytheiab-8NoncodingRNA
MaheshwarGummalla1,RobertK.Maeda1,JavierJ.CastroAlvarez1,HenrikGyurkovics2,
SwethaSingari3,KevinA.Edwards3,Franc?oisKarch1*,WelcomeBender4*
1Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland, 2Institute of Genetics, Biological Research Center, Szeged, Hungary, 3School of
BiologicalSciences,IllinoisStateUniversity,Normal,Illinois,UnitedStatesofAmerica,4DepartmentofBiologicalChemistryandMolecularPharmacology,HarvardMedical
School,Boston,Massachusetts,UnitedStatesofAmerica
Abstract
ThehomeoticgenesinDrosophilamelanogasterarealignedonthechromosomeintheorderofthebodysegmentsthat
theyaffect.Thegenesaffectingthemoreposteriorsegmentsrepressthemoreanteriorgenes.Thisposteriordominance
rulemustbequalifiedinthecaseofabdominal-A(abd-A)repressionbyAbdominal-B(Abd-B).AnimalslackingAbd-Bshow
ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system.
Repressionintheseneuronalcellsisaccomplishedbya92kbnoncodingRNA.This‘‘iab-8RNA’’producesamicroRNAto
repressabd-A,butalsohasasecond,redundantrepressionmechanismthatactsonly‘‘incis.’’Transcriptionalinterference
withtheabd-Apromoteristhemostlikelymechanism.
Citation: Gummalla M, Maeda RK, Castro Alvarez JJ, Gyurkovics H, Singari S, et al. (2012) abd-A Regulation by the iab-8 Noncoding RNA. PLoS Genet 8(5):
e1002720.doi:10.1371/journal.pgen.1002720
Editor:NorbertPerrimon,HarvardMedicalSchool,HowardHughesMedicalInstitute,UnitedStatesofAmerica
ReceivedNovember14,2011;AcceptedApril3,2012;PublishedMay24,2012
Copyright: ? 2012 Gummalla et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThisworkwassupportedbyagrantfromOtkatoHG;agrantfromtheNationalInstitutesofHealthtoKAE;grantsfromtheSwissNationalFundfor
Research,theNCCRFrontiersinGenetics
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