FoldingKineticsofChymotrypsinInhibitor2.pptVIP

Folding Kinetics of Chymotrypsin Inhibitor 2 Jennifer Kuge MRL Research Experience for Teachers 2007 Mentor: Camille Lawrence Plaxco Lab- Funded by ICB Background Information: Proteins are a chain of amino acids Chymotrypsin Inhibitor 2 (CI2) is a small, single domain protein (~80 amino acids) Protease inhibitor found in barley What started this research… Most point mutations: lead to very little change to the folding rate slow down the folding rate When Arg48 is changed to Phe48 in CI2, it accelerates the folding rate What feature of a substitution to Phe48 from Arg48 in CI2 contributes to