Accuracy and User-Acceptability of HIV Self-Testing Using an Oral Fluid-Based HIV Rapid Test 英文参考文献.docVIP

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Accuracy and User-Acceptability of HIV Self-Testing Using an Oral Fluid-Based HIV Rapid Test 英文参考文献.doc

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Accuracy and User-Acceptability of HIV Self-Testing Using an Oral Fluid-Based HIV Rapid Test 英文参考文献

AccuracyandUser-AcceptabilityofHIVSelf-Testing UsinganOralFluid-BasedHIVRapidTest OonTekNg1*,AngelaL.Chow2,3,VernonJ.Lee2,3,MarkI.C.Chen2,3,MarKyawWin2,HiokHeeTan4, ArleneChua1,YeeSinLeo1 1Department of Infectious Disease, Tan Tock Seng Hospital, Singapore, 2Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore, 3Department of EpidemiologyandPublicHealth,NationalUniversityofSingapore,Singapore,4DepartmentofSexuallyTransmittedInfectionControl,NationalSkinCentre,Singapore Abstract Background: The United States FDA approved an over-the-counter HIV self-test, to facilitate increased HIV testing and earlierlinkagetocare.Weassessedtheaccuracyofself-testingbyuntrainedparticipantscomparedtohealthcareworker (HCW)testing,participants’abilitytointerpretsampleresultsanduser-acceptabilityofself-testsinSingapore. Methodology/PrincipalFindings:Across-sectionalstudy,involving200knownHIV-positivepatientsand794unknownHIV statusat-riskparticipantswasconducted.Participants(allwithoutpriorself-testexperience)performedself-testingguided solelybyvisualinstructions,followedbyHCWtesting,bothusingtheOraQuickADVANCERapidHIV1/2AntibodyTest,with both results interpreted by the HCW. To assess ability to interpret results, participants were provided 3 sample results (positive, negative, and invalid) to interpret. Of 192 participants who tested positive on HCW testing, self-testing was positivein186(96.9%),negativein5(2.6%),andinvalidin1(0.5%).Of794participantswhotestednegativeonHCWtesting, self-testingwasnegativein791(99.6%),positivein1(0.1%),andinvalidin2(0.3%).Excludinginvalidtests,self-testinghad sensitivityof97.4%(95%CI95.1%to99.7%)andspecificityof99.9%(95%CI:99.6%to100%).Wheninterpretingresults, 96%,93.1%and95.2%correctlyreadthepositive,negativeandinvalidrespectively.Therewerenosignificantdemographic predictorsforfalsenegativeself-testingorwronglyinterpretingpositiveorinvalidsampleresultsasnegative.Eighty-seven percentwouldpurchasethekitover-the-counter;89%preferredtotakeH