Acute Human Self-Poisoning with Imidacloprid Compound A Neonicotinoid Insecticide 英文参考文献.docVIP

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Acute Human Self-Poisoning with Imidacloprid Compound A Neonicotinoid Insecticide 英文参考文献.doc

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Acute Human Self-Poisoning with Imidacloprid Compound A Neonicotinoid Insecticide 英文参考文献

AcuteHumanSelf-PoisoningwithImidacloprid Compound:ANeonicotinoidInsecticide FahimMohamed1*,IndikaGawarammana1,ThomasA.Robertson2,MichaelS.Roberts2 ,Chathura Palangasinghe1,ShukryZawahir1,ShalukaJayamanne3,JaganathanKandasamy4,MichaelEddleston1,5, NickA.Buckley1,6,AndrewH.Dawson1,7,DarrenM.Roberts1,8 1SouthAsianClinicalToxicologyResearchCollaboration,DepartmentofClinicalMedicine,UniversityofPeradeniya,Peradeniya,SriLanka,2TherapeuticsResearchUnit, School of Medicine, University of Queensland, Brisbane, Australia, 3Polonnaruwa General Hospital, North Central Province, Polonnaruwa, Sri Lanka, 4Anuradhapura GeneralHospital,NorthCentralProvince,Anuradhapura,SriLanka,5ScottishPoisonsInformationBureau,RoyalInfirmaryofEdinburgh,andClinicalPharmacologyUnit, Universityof Edinburgh, Edinburgh, United Kingdom, 6MedicalProfessorial Unit, POWHospitalClinical School, University ofNew SouthWales, Kensington, Australia, 7School of Medicine and Public Health, University of Newcastle, Callaghan, Australia, 8Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane,Australia Abstract Background: Deliberate self-poisoning with older pesticides such as organophosphorus compounds are commonly fatal and a serious public health problem in the developing world. The clinical consequences of self-poisoning with newer pesticides are not well described. Such information may help to improve clinical management and inform pesticide regulators of their relative toxicity. This study reports the clinical outcomes and toxicokinetics of the neonicotinoid insecticideimidaclopridfollowingacuteself-poisoninginhumans. Methodology/PrincipalFindings:Demographicandclinicaldatawereprospectivelyrecordedinpatientswithimidacloprid exposure in three hospitals in Sri Lanka. Blood samples were collected when possible for quantification of imidacloprid concentration.Therewere68patients(61self-ingestionsand7dermalexposures)withexposuretoimidacloprid.Ofthe self-poisoningpatients,themediantim