Bayesian Hierarchical Models Combining Different Study Types and Adjusting for Covariate Imbalances A Simulation Study to Assess Model Performance 英文参考文献.docVIP

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Bayesian Hierarchical Models Combining Different Study Types and Adjusting for Covariate Imbalances A Simulation Study to Assess Model Performance 英文参考文献.doc

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Bayesian Hierarchical Models Combining Different Study Types and Adjusting for Covariate Imbalances A Simulation Study to Assess Model Performance 英文参考文献

BayesianHierarchicalModelsCombiningDifferentStudy TypesandAdjustingforCovariateImbalances:A SimulationStudytoAssessModelPerformance C.ElizabethMcCarron1,2*,EleanorM.Pullenayegum1,3,LehanaThabane1,3,RonGoeree1,2 ,Jean-Eric Tarride1,2 1Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, 2Programs for Assessment of Technology in Health (PATH) ResearchInstitute,St.Joseph’sHealthcareHamilton,Hamilton,Ontario,Canada,3BiostatisticsUnit,St.Joseph’sHealthcareHamilton,Hamilton,Ontario,Canada Abstract Background:Bayesianhierarchicalmodelshavebeenproposedtocombineevidencefromdifferenttypesofstudydesigns. However, when combining evidence from randomised and non-randomised controlled studies, imbalances in patient characteristics between study armsmay biasthe results.The objectiveof this study was toassess theperformance ofa proposedBayesianapproachtoadjustforimbalancesinpatientlevelcovariateswhencombiningevidencefrombothtypes ofstudydesigns. Methodology/PrincipalFindings:Simulationtechniques,inwhichthetruthisknown,wereusedtogeneratesetsofdata for randomised and non-randomised studies. Covariate imbalances between study arms were introduced in the non- randomisedstudies.TheperformanceoftheBayesianhierarchicalmodeladjustedforimbalanceswasassessedintermsof bias.ThedatawerealsomodelledusingthreeotherBayesianapproachesforsynthesisingevidencefromrandomisedand non-randomised studies. The simulations considered six scenarios aimed at assessing the sensitivity of the results to changes in the impact of the imbalances and the relative number and size of studies of each type. For all six scenarios considered, the Bayesian hierarchical model adjusted for differences within studies gave results that were unbiased and closesttothetruevaluecomparedtotheothermodels. Conclusions/Significance: Where informed health care decision making requires the synthesis of evidence from randomised and non-randomised study designs, the proposed hierarchica