Dicer Is Required for Maintaining Adult Pancreas 英文参考文献.docVIP

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Dicer Is Required for Maintaining Adult Pancreas 英文参考文献.doc

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Dicer Is Required for Maintaining Adult Pancreas 英文参考文献

DicerIsRequiredforMaintainingAdultPancreas SumiyoMorita1,2,AkemiHara3,ItaruKojima3,TakuroHorii1,MikaKimura1,2,TadahiroKitamura4, TakahiroOchiya5,KatsumiNakanishi6,RyoMatoba6,KenichiMatsubara6,IzuhoHatada1* 1LaboratoryofGenomeScience,BiosignalGenomeResourceCenter,InstituteforMolecularandCellularRegulation,GunmaUniversity,Showa-machiMaebashi,Japan, 2JapanHealthSciencesFoundation,Chuo,Tokyo,Japan,3DepartmentofMolecularMedicine,InstituteforMolecularandCellularRegulation,GunmaUniversity,Showa- machiMaebashi,Japan,4MetabolicSignalResearchCenterLaboratoryofMetabolicSignal,InstituteforMolecularandCellularRegulation,GunmaUniversity,Showa- machi Maebashi, Japan, 5National Cancer Center Research Institute, Section for Studies on Metastasis, Tsukiji, Chuo-ku, Tokyo, Japan, 6DNA Chip Research Inc., Suehirocho,Tsurumi-ku,Yokohama,Japan Abstract Dicer1, an essential component of RNA interference and the microRNA pathway, has many important roles in the morphogenesisofdevelopingtissues.Dicer1nullmicehavebeenreportedtodieatE7.5;thereforeitisimpossibletostudy itsfunctioninadulttissues.WepreviouslyreportedthatDicer1-hypomorphicmice,whoseDicer1expressionwasreducedto 20% in all tissues, were unexpectedly viable. Here we analyzed these mice to ascertain whether the down-regulation of Dicer1expressionhasanyinfluenceonadulttissues.Interestingly,alltissuesofadult(8–10weekold)Dicer1-hypomorphic micewerehistologicallynormalexceptforthepancreas,whosedevelopmentwasnormalatthefetalandneonatalstages; however,morphologicabnormalitiesinDicer1-hypomorphicmiceweredetectedafter4weeksofage.Thissuggestedthat Dicer1isimportantformaintainingtheadultpancreas. Citation: Morita S, Hara A, Kojima I, Horii T, Kimura M, et al. (2009) Dicer Is Required for Maintaining Adult Pancreas. PLoS ONE 4(1): e4212. doi:10.1371/ journal.pone.0004212 Editor:KerbyShedden,UniversityofMichigan,UnitedStatesofAmerica ReceivedOctober22,2008;AcceptedDecember9,2008;PublishedJanuary16,2009 Copyright: ? 2009 Morita et al. This is a