原创力文档Lack of Effect of Lowering LDL Cholesterol on Cancer Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy 英文参考文献.docVIP
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Lack of Effect of Lowering LDL Cholesterol on Cancer Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy 英文参考文献
LackofEffectofLoweringLDLCholesterolonCancer:
Meta-AnalysisofIndividualDatafrom175,000Peoplein
27RandomisedTrialsofStatinTherapy
CholesterolTreatmentTrialists’(CTT)Collaboration*
Abstract
Background:Statintherapyreducestheriskofocclusivevascularevents,butuncertaintyremainsaboutpotentialeffectson
cancer.WesoughttoprovideadetailedassessmentofanyeffectsoncancerofloweringLDLcholesterol(LDL-C)witha
statinusingindividualpatientrecordsfrom175,000patientsin27large-scalestatintrials.
MethodsandFindings:Individualrecordsof134,537participantsin22randomisedtrialsofstatinversuscontrol(median
duration4.8y
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