Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase 英文参考文献.docVIP

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Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase 英文参考文献.doc

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Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase 英文参考文献

MouseHORMAD1andHORMAD2,TwoConserved MeioticChromosomalProteins,AreDepletedfrom SynapsedChromosomeAxeswiththeHelpofTRIP13 AAA-ATPase LukaszWojtasz1.,KatrinDaniel1.,IgnasiRoig2,EwelinaBolcun-Filas3,HuilingXu4 ,Verawan Boonsanay1,ChristianR.Eckmann5,HowardJ.Cooke6,MariaJasin7,ScottKeeney2,8,MichaelJ.McKay9, AttilaToth1* 1InstituteofPhysiologicalChemistry,TechnischeUniversita¨t Dresden,Dresden,Germany,2MolecularBiologyProgram,MemorialSloan-KetteringCancerCenter,New York, New York, United States of America, 3Cornell University, Ithaca, New York, United States of America, 4Divisions of Radiation Oncology and Research, Peter MacCallumCancerCentre,Melbourne,Victoria,Australia,5MaxPlanckInstituteofMolecularCellBiologyandGenetics,Dresden,Germany,6MedicalResearchCouncil HumanGeneticsUnit,WesternGeneralHospital,Edinburgh,UnitedKingdom,7DevelopmentalBiologyProgram,MemorialSloan-KetteringCancerCenter,NewYork,New York, United States of America, 8Howard Hughes Medical Institute, New York, New York, United States of America, 9Department of Radiation Oncology, Australian NationalUniversityandtheCanberraHospital,Canberra,AustralianCapitalTerritory,Australia Abstract Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are repaired by recombination from homologouschromosomes(homologues).Inawidevarietyoforganisms,meioticHORMA-domainproteinsarerequiredto direct DSB repair towards homologues. This inter-homologue bias is required for efficient homology search, homologue alignment,andcrossoverformation.HORMA-domainproteinsarealsoimplicatedinotherprocessesrelatedtocrossover formation, including DSB formation, inhibition of promiscuous formation of the synaptonemal complex (SC), and the meiotic prophasecheckpoint that monitors both DSB processing andSCs. We examined the behaviorof two previously uncharacterized meiosis-specific mouse HORMA-domain proteins—HORMAD1 and HORMAD2—in wild-type mice and in mutants defective in DSB processing or SC formation. HORMADs are