PK_PD理论在抗菌素应用中的意义要点.pptVIP

延长点滴时间 Parametera (U) 1g,q8h间歇注射 q8h,3h 注射 1 g 2 g Cmax (μg/ml) 112.52 ± 34.33 30.24 ± 10.71 67.09 ± 31.00 MIC %T MIC (μg/ml) 16 28.33 ± 11.67 37.78 ± 20.57 57.89 ± 24.26 8 45.89 ± 22.90 58.11 ± 24.38 72.89 ± 22.40 4 57.00 ± 24.82 72.67 ± 21.97 85.56 ± 16.42 1 74.67 ± 17.94 93.56 ± 6.84 98.56 ± 3.28 美平：半小时注射和延长注射时间的药效学比较 Jaruratanasirikul S, Antimicrob Agents Chemother. 2005;49(4):1337-9. 美平不同给药方案抗铜绿假单胞菌达标率 MIC % 抑菌率 1g q8h 3h 1g q8h 1h 0.5 q8h 3h 0.5 q8h 1h 0.5 q6h 1h 0.25 100 99.97 100 98.65 99.84 0.5 100 99.82 100