Prevalence and Follow-Up of Occult HCV Infection in an Italian Population Free of Clinically Detectable Infectious Liver Disease 英文参考文献.docVIP

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Prevalence and Follow-Up of Occult HCV Infection in an Italian Population Free of Clinically Detectable Infectious Liver Disease 英文参考文献.doc

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Prevalence and Follow-Up of Occult HCV Infection in an Italian Population Free of Clinically Detectable Infectious Liver Disease 英文参考文献

PrevalenceandFollow-UpofOccultHCVInfectioninan ItalianPopulationFreeofClinicallyDetectableInfectious LiverDisease LauraDeMarco1*,PaolaManzini2,MorenaTrevisan1,AnnaGillio-Tos1,FrancaDanielle2,CinziaBalloco2, AlessandraPizzi2,EleonoraDeFilippo2,SergioD’Antico2,BeatriceViolante2,AdrianoValfre`2, FrancoCurti2,FrancoMerletti1,3,LorenzoRichiardi1,3 1Unit of Cancer Epidemiology, C.E.R.M.S., University of Turin, Turin, Italy, 2Blood Bank, A.O.U. S. Giovanni Battista, Turin, Italy, 3Center for Oncologic Prevention, UniversityofTurin,Turin,Italy Abstract Background: Occult hepatitis C virus infection (OCI) is a recently described phenomenon characterized by undetectable levelsofHCV-RNAinserum/plasmabycurrentlaboratoryassays,withidentifiablelevelsinperipheralbloodmononuclear cells(PBMCs)and/orlivertissuebymoleculartestswithenhancedsensitivity.Previousresultsfromourgroupshowedan OCIprevalenceof3.3%inapopulationunselectedforhepaticdisease.ThepresentstudyaimedtoevaluateOCIprevalence in a larger cohort of infectious liver disease-free (ILDF) subjects. Clinical follow-up of OCI subjects was performed to investigatethenaturalhistoryoftheinfection. MethodsandFindings:439subjectsreferredtoaTurinBloodBankforphlebotomytherapywererecruited.Theyincluded 314ILDFsubjects,40HCV-positivesubjectsand85HBV-positivesubjects,ofwhom7wereactiveHBVcarriers.Sixsubjects (4/314 ILDF subjects [1.27%] and 2/7 active HBV carriers [28%]) were positive for HCV-RNA in PBMCs, but negative for serological and virological markers of HCV, indicating OCI. HCV genotypes were determined in the PBMCs of 3/6 OCI subjectstwohadtype1b;theotherhadtype2a/2c.OCIsubjectswerefollowedupforatleast2years.After12monthsonly oneOCIpersisted,showingalowHCVviralload(3.736101UI/ml).Bytheendoffollow-upallOCIsubjectswerenegativefor HCV.Noseroconversion,alterationofliverenzymelevels,orreductionofliversynthesisoccurredduringfollow-up. Conclusions:ThisstudydemonstratedtheexistenceofOCIinILDFsubjects,andsuggestedahighOCIprevalenceamong a