Relationship of tooth loss to mild memory impairment and cognitive impairment findings from the fujiwara-kyo study 英文参考文献.docVIP

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Relationship of tooth loss to mild memory impairment and cognitive impairment findings from the fujiwara-kyo study 英文参考文献.doc

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Relationship of tooth loss to mild memory impairment and cognitive impairment findings from the fujiwara-kyo study 英文参考文献

Okamotoetal.BehavioralandBrainFunctions2010,6:77 /content/6/1/77 RESEARCH OpenAccess Relationshipoftoothlosstomildmemory impairmentandcognitiveimpairment:findings fromthefujiwara-kyostudy NozomiOkamoto1*,MasayukiMorikawa2,3,KensukeOkamoto4,5,NoboruHabu1,JunkoIwamoto6,KimikoTomioka1, KeigoSaeki1,MotokazuYanagi7,NobukoAmano7,NorioKurumatani1 Abstract Background:Thiscross-sectionalstudyinvestigatedtherelationshipbetweenthenumberofremainingteethto mildmemoryimpairment(MMI),whichisapreclinicalstageofdementia,andtocognitiveimpairment. Methods:Thesubjectswereaged65yearsorolderandweregroupedaccordingtotheirscorefortheMini- MentalStateExamination(MMSE),thethree-worddelayedrecalltestintheMMSE,andtheGeriatricDepression Scaleintothecontrolgroup(n=3,696),theMMIgroup(n=121),andthelowMMSEscore(23orlower)group (n=214).Wecollecteddataonthenumberofremainingteeth,thelengthoftheedentulousperiod,health- relatedlifestyle,medicalhistory,bloodpressure,height,andbodyweight.Fastingvenousbloodsampleswerealso obtained. Results:Multiplelogisticregressionanalysis,adjustedfordepressivesymptoms,age,sex,lengthofeducation,and otherexplanatoryvariables,revealedthattheoddsratiosof0-10remainingteethto22-32remainingteethwere 1.679(95%CI1.073-2.627)forMMIand2.177(95%CI1.510-3.140)foralowMMSEscore.Asignificantrelationship wasalsofoundbetweenthelengthoftheedentulousperiodandtheriskofalowMMSEscore(oddsratio3.102, 95%CI1.432-6.720)(15yearsormore/lessthan15years). Conclusions:Ourfindingssuggestthattoothlossisassociatedwithcognitivefunction. Background Among individuals with mild memory impairment Toothloss,oneoftheindicators ofperiodontal disease (MMI), 21.2% progressed to illnesses with dementia, [1,2], has been reported to be associated with Alzhei- including AD (10.6%), vascular dementia (4.8%), or mer’sdisease(AD)anddementia[3,4].Individualswith othertypesofdementia(5.8%),overaperiodof5years clinical dementia have an increased deterioration of [12];therefore,theyrepresentahigh-riskpopulationf