视黄酸使用说明.pdfVIP

all trans-RETINOIC ACID Sigma Prod. No. R 2625 CAS NUMBER: 302-79-4 SYNONYMS: Vitamin A Acid; Retinoic Acid; Tretinoin1; all-trans- CH Vitamin A Acid; all-(E)-Retinoic Acid; all-trans-ß- 3 CH Retinoic Acid; Retin 1 3 O 2 H C CH A 3 3 C OH PHYSICAL DESCRIPTION: Appearance: Yellow to yellow with an orange cast powder3 CH Molecular formula: C20 H28O2 3 Molecular weight: 300.4 EM(351nm) = 45,000 (methanol)4 EM(350nm) = 44,300 (ethanol)5 Melting point: 180-182°C4 Purity: 98% by HPLC3 Acid or alkaline impurities in absolute ethanol affect the absorption maxima and extinction coefficients of retinoic acid (RA) solutions.5 The observed maximum wavelength of about 349.6 nm for RA dissolved in USP grade ethanol was shifted to 336-337 nm upon addition of 2 drops of 0.01 N NaOH to 1 ml of the solution. The maximum wavelength shifted back to about 349.6 upon addition of 2 drops of 0.01 N HCl to 1 ml of the above solution.3,5 Methods for assaying purity have been reported.6 METHOD OF PREPARATION: RA is synthetically prepared.7 A method of preparation and purification has been reported.5 STABILITY / STORAGE AS SUPPLIED: RA is expected to be stable for at least one year when stored at -20°C unopened in the ampule (packaged under a