Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells 英文参考文献.docVIP

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Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells 英文参考文献.doc

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Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells 英文参考文献

Molecules 2012, 17, 14899-14907; doi:10.3390/molecules171214899 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two New Oleanane-Type Triterpenoids from Platycodi Radix and Anti-proliferative Activity in HSC-T6 Cells Qin Zhan 1, Feng Zhang 1, Lianna Sun 2, Zhijun Wu 1 and Wansheng Chen 1,* 1 Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China; E-Mails: zhanqin5@ (Q.Z.); fengzhangky@ (F.Z.); wuzhijun999@ (Z.W.) 2 School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; E-Mail: sssnmr@ * Author to whom correspondence should be addressed; E-Mail: chenwanshengsmmu@; Tel./Fax: +86-21-8188-6181. Received: 9 November 2012; in revised form: 29 November 2012 / Accepted: 30 November 2012 / Published: 13 December 2012 Abstract: Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 1–7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line. Keywords: Platycodon grandiflorum; oleanane-type triterpenoid; triterpenoid saponin 1. Introduction Platycodon grandiflorum A. DC. is a perennial plant in the family Campanulaceae which grows widely in East Asia. Platycodi Radix, the root of P. grandiflorum, has been used in traditional Oriental medicine as an expectorant for pulmonary disease and a remedy for respiratory disorders [1,2]. Platycodi Radix has