Simultaneous multiplexed quantification of caffeine and its major metabolites theobromine and paraxanthine using surface-enhanced Raman scattering.PDF

Anal Bioanal Chem (2015) 407:8253–8261 DOI 10.1007/s00216-015-9004-8 RESEARCH PAPER Simultaneous multiplexed quantification of caffeine and its major metabolites theobromine and paraxanthine using surface-enhanced Raman scattering Omar Alharbi 1 Yun Xu 1 Royston Goodacre 1 Received: 12 February 2015 /Revised: 19 August 2015 /Accepted: 25 August 2015 /Published online: 7 September 2015 # The Author(s) 2015. This article is published with open access at S Abstract Accurate quantitative measurement of drugs and analysis of multiple analytes simultaneously without